4.5 Article

Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with leflunomide

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biotechnology & Applied Microbiology

Rodent Preclinical Models for Developing Novel Antiarthritic Molecules: Comparative Biology and Preferred Methods for Evaluating Efficacy

Brad Bolon et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)

Article Chemistry, Medicinal

Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)

Hiroyuki Abe et al.

ACS MEDICINAL CHEMISTRY LETTERS (2011)

Review Rheumatology

Treatment of rheumatoid arthritis: state of the art 2009

Ronald F. van Vollenhoven

NATURE REVIEWS RHEUMATOLOGY (2009)

Article Biochemistry & Molecular Biology

Pharmacologic inhibition of Tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood*

J. Perry Hall et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Chemistry, Medicinal

Gini coefficient: A new way to express selectivity of kinase inhibitors against a family of kinases

Piotr P. Graczyk

JOURNAL OF MEDICINAL CHEMISTRY (2007)

Article Hematology

Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma

Iris Breitkreutz et al.

BRITISH JOURNAL OF HAEMATOLOGY (2007)

Article Pharmacology & Pharmacy

FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice

Makoto Ohori et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2007)

Article Biochemistry & Molecular Biology

Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex

M Ohori et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Oncology

Targeting the mitogen-activated protein kinase cascade to treat cancer

JS Sebolt-Leopold et al.

NATURE REVIEWS CANCER (2004)

Article Endocrinology & Metabolism

Role of osteoclast extracellular signal-regulated kinase (ERK) in cell survival and maintenance of cell polarity

H Nakamura et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2003)

Review Multidisciplinary Sciences

Evolving concepts of rheumatoid arthritis

GS Firestein

NATURE (2003)

Article Biochemistry & Molecular Biology

IL-1 alpha stimulation of osteoclast survival through the PI-3 kinase/Akt and ERK pathways

SH Lee et al.

JOURNAL OF BIOCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-α supports the survival of osteoclasts through the activation of Akt and ERK

SE Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)