期刊
INFLAMMATION RESEARCH
卷 60, 期 4, 页码 389-398出版社
SPRINGER BASEL AG
DOI: 10.1007/s00011-010-0283-4
关键词
Aspirin; Macrophages; Phagocytosis; Immunogenicity
资金
- National Natural Science Foundation for Key Programs [C30630060]
- National Natural Science Foundation for Distinguished Young Scholars [C03020504]
- Chinese Academy of Sciences [KSCX2-SW-333]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry [2005-546]
The effect of acetylsalicyclic acid (ASA) on the phagocytosis and immunogenicity of macrophages remains to be determined. BALB/c mice and peritoneal macrophages were used. BALB/c mice were treated with ASA (0, 6, or 60 mg/kg/day) intraperitoneally for 1 week. Flow cytometry and phagocytosis assay were employed. ASA significantly decreased cell numbers, nonopsonic phagocytosis, and immunogenicity as well as changing the phenotypes of peritoneal macrophages in vivo. After in vitro treatment with ASA, macrophages expressed low levels of MHC-II, CD80, and CD47 molecules, and showed significantly decreased phagocytosis. Importantly, ASA blocked the differentiation of macrophages from bone marrow cells in vitro as indicated by decreased macrophage cell numbers and phenotype alteration. The present study provides basic information on the direct effect of ASA on macrophages, supporting the potential application of ASA in patients with allo-grafts or autoimmune diseases.
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