期刊
INFLAMMATION RESEARCH
卷 58, 期 8, 页码 503-512出版社
SPRINGER BASEL AG
DOI: 10.1007/s00011-009-0016-8
关键词
Crohn's disease; Galectin-3; Disease marker; Mucosal immunity; Ulcerative colitis
资金
- Czech Science Foundation [310/08/H077, 303/060/974]
- Academy of Sciences [S500200572]
- Ministry of Education, Youth and Sports of the Czech Republic [2B06155, MSM0021620806, 1M0538]
- Institute of Microbiology [AV0Z50200510]
- Ministry of Health [NR8963-3]
- Verein zur Forderung des biologisch-technologischen Fortschritts in der Medizin e. V.
- EU [MCRTN-CT-2005-19561]
It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease. Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections. Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn's disease, associated with emerging positivity of CD14(+) cells. Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.
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