期刊
INFLAMMATION
卷 38, 期 3, 页码 1191-1200出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-014-0083-z
关键词
interleukin-22; human beta-defensin-2; A549 cells; signalling pathway
Human beta-defensin-2(HBD-2) is one of the two major vertebrate antimicrobial peptide families (alpha and beta), which is highly expressed by proinflammatory induction in the lung and exhibit broad-spectrum antimicrobial activity. We observed that IL-22 receptors high expressed on the membrane of A549 cells; HBD-2 mRNA was expressed in a time-and concentration-dependent manners in A549 cells when treated with IL-22; further studies demonstrated that HBD-2 expression was attenuated by AG490, but to JSH-23, inhibitors of p-STAT3 DNA binding and NF-kappa B/p65 subunit nuclear translocation, respectively. These results support that IL-22-mediated signalling pathway of HBD-2 gene expression involved STAT3 but not NF-kappa B in human alveolar epithelium. These findings provide a new insight into how IL-22 may play an important link between innate and adaptive immunity, thereby anti-infection locally in the alveolar epithelium.
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