期刊
INFLAMMATION
卷 38, 期 3, 页码 941-948出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-014-0056-2
关键词
JEUD-38; sesquiterpene lactone; NO; NF-kappa B; MAPK
资金
- National Natural Science Foundation of China [81373441, 81202542, 81402802]
- Natural Science Foundation of Tianjin [12JCZDJC25800, 13JCYBJC24800]
- New Teachers' Fund for Doctor Stations from Ministry of Education, China [20121202120009]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- 211 project of Tianjin Medical University
- Japan Society for the Promotion of Science [FY2013, BR131302]
We isolated JEUD-38, a new sesquiterpene lactone from Inula japonica Thunb. JEUD-38 dramatically attenuated lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Consistent with this finding, the protein expression of inducible nitric oxide synthase (iNOS) was blocked by JEUD-38 in a concentration-dependent manner. To elucidate the mechanism, we examined the effect of JEUD-38 on LPS-stimulated nuclear factor-kappa B (NF-kappa B) nuclear translocation, inhibitory factor-kappa B (I kappa B) phosphorylation, and degradation. JEUD-38 reduced the translocation of p65, via abrogating I kappa B-alpha phosphorylation and degradation. In addition, JEUD-38 inhibited LPS-stimulated phosphorylation of mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38. Since iNOS as well as the upstream NF-kappa B and MAPKs are known to be closely involved in inflammation, these results suggest that JEUD-38 is a promising candidate for prevention and therapy of inflammatory diseases.
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