期刊
INFLAMMATION
卷 36, 期 1, 页码 26-34出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-012-9516-8
关键词
resveratrol; polydatin; HaCat
资金
- GLURES, s.r.l. Academic SPIN-OFF Ca' Foscari University of Venice, Italy
It is well known that human keratinocytes produce the anti-microbial peptide beta-defensin 2. Its production is enhanced by pathogenic microorganisms or other environmental stressors. In this study, we evaluated the effect of resveratrol, a polyphenol found in several dietary source as grape seed, and its natural precursor, polydatin on heat-stressed human keratinocytes. By reverse transcription-polymerase chain reaction and enzyme-linked immunoadsorbent assay, we demonstrated that resveratrol used in combination with polydatin was able to modulate interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha gene expression. In addition, our data show that resveratrol and polydatin increased the heat shock protein (Hsp)70B' gene expression, a Hsp that plays an important role in the cytoprotection and repair of cells and tissues. Worthy of note, polydatin used alone or in combination with resveratrol, increased the release of human beta-defensin 2. These results highlighted the ability of polydatin and resveratrol to reinforce cytoprotective response in stress conditions and suggest their use in cosmetic or pharmaceutical preparations.
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