期刊
INFLAMMATION
卷 36, 期 2, 页码 259-271出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-012-9542-6
关键词
Ecklonia stolonifera; phlorofucofuroeckol A; cytokine; microglia; nuclear factor-kappa B;; inflammation
资金
- Fishery Commercialization Technology Development of Ministry for Food, Agriculture, Forestry and Fisheries [iPET109200-3]
- Brain Busan 21 Program, Republic of Korea
Microglial activation has been implicated in many neurological disorders for its inflammatory and neurotrophic effects. In this study, we investigated the effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera Okamura on the production of inflammatory mediators in lipopolysaccharide (LPS)-stimulated microglia. Pre-treatment of phlorofucofuroeckol A attenuated the productions of nitric oxide, prostaglandin E-2, and pro-inflammatory cytokines in LPS-stimulated microglia. Profoundly, phlorofucofuroeckol A treatment showed inactivation of nuclear factor-kappa B (NF-kappa B) by preventing the degradation of inhibitor kappa B-alpha and the nuclear translocation of p65 NF-kappa B subunit. Moreover, phlorofucofuroeckol A inhibited the activation of c-Jun NH2-terminal kinases (JNKs), p38 mitogen-activated protein kinase (MAPK), and Akt, but not that of extracellular signal-regulated kinase. These results indicate that phlorofucofuroeckol A inhibits the LPS-induced expression of inflammatory mediators through inactivation of NF-kappa B, JNKs, p38 MAPK, and Akt pathways. These findings suggest that phlorofucofuroeckol A can be considered as a nutraceutical candidate for the treatment of neuroinflammation in neurodegenerative diseases.
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