期刊
INFLAMMATION
卷 35, 期 4, 页码 1392-1401出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-012-9452-7
关键词
resveratrol; respiratory syncytial virus; toll-like receptor; inflammation; airway epithelial cell
资金
- Program for New Century Excellent Talents in University [06-775]
- Chongqing Medical University
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20105503120003]
Respiratory syncytial virus (RSV) is the most common pathogen responsible for lower respiratory diseases in children. So far, there is no effective treatment or preventative vaccine available for RSV infection, although ribavirin and dexamethasone are commonly prescribed. Resveratrol has been shown to inhibit the replication of several other viruses, thus the effect of resveratrol on RSV-induced inflammatory mediators in 9HTEo cell cultures was evaluated, and possible mechanisms of action were explored and compared with dexamethasone and ribavirin. Incubation with resveratrol resulted in decreased IL-6 production and partial inhibition of RSV replication. Resveratrol treatment also inhibited virus-induced TIR-domain-containing adapter-inducing interferon-beta (TRIF) and TANK binding kinase 1 (TBK1) protein expression. These data demonstrate the ability of resveratrol to inhibit cytokine production by RSV in airway epithelial cells, indicating that it might be a therapeutic agent with both anti-inflammatory and antiviral potential for the treatment of RSV infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据