期刊
INFLAMMATION
卷 35, 期 6, 页码 1793-1797出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-012-9499-5
关键词
Z-Ligustilide; inflammation; osteoporosis; ELISA
The purpose of the present study was to investigate the anti-inflammatory activity of Z-Ligustilide (LIG) in experimental ovariectomized (OVX) osteopenic rats. The anti-inflammatory potential of LIG in the regulation of nuclear factor kappa B (NF-kappa B), maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1 beta (IL-1 beta), inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha), adhesion molecule (ICAM-1) and cyclooxygenase-2 (COX-2) was determined by ELISA. LIG significantly inhibited OVX-induced up-regulation of NF-kappa B activation and the production of IL-1 beta, TNF-alpha, iNOS, ICAM-1 and COX-2. Moreover, LIG suppressed MDA and infiltration of PMN. The results of the present study clearly demonstrate that there may be an inflammatory component in the etiology of osteoporosis. It revealed a significant anti-inflammatory effect of Z-Ligustilide in experimental OVX osteopenic rats.
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