期刊
INFECTION GENETICS AND EVOLUTION
卷 22, 期 -, 页码 94-102出版社
ELSEVIER
DOI: 10.1016/j.meegid.2014.01.010
关键词
Astrovirus; Virus evolution; Recombination; Phylogeny
资金
- Russian Foundation for Basic Research [13-04-00554a]
Complete genome sequences of previously unstudied human astrovirus subgenotypes - HAstV-2a and HAstV-2c - and two isolates of a rare genotype HAstV-4 have been determined. These isolates were recovered from fecal samples of young children hospitalized with acute intestinal infections in Novosi-birsk (Russia). Three of the four sequenced isolates (HAstV-2a, HAstV-2c, and HAstV-4) are recombinants. It has been shown that all known HAstV-2 genomes have emerged via recombination; the HAstV-1 and HAstV-4 genotypes contain both recombinant and non-recombinant isolates; and all HAstV-3, HAstV-5, and HAstV-6 whole-genome sequences display no reliable signs of recombination. The average mutation accumulation rate has been determined based on an extended ORF2 fragment and amounts to 1.0 x 10(-3) substitutions per site per year. The evolutionary chronology of current HAstV genotypes has been reconstructed. (C) 2014 Elsevier B.V. All rights reserved.
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