期刊
INFECTION GENETICS AND EVOLUTION
卷 21, 期 -, 页码 593-601出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2013.04.022
关键词
Staphylococcus aureus; Phage; Classification; Genomics; Virulence factor; Adaptation
资金
- DFG (German Research Foundation) [SFB766]
- BMBF (German Federal Ministry of Education and Research) [TTU.08.807]
Most of the dissimilarity between Staphylococcus aureus strains is due to the presence of mobile genetic elements such as bacteriophages or pathogenicity islands. These elements provide the bacteria with additional genes that enable them to establish a new lifestyle that is often accompanied by a shift to increased pathogenicity or a jump to a new host. S. aureus phages may carry genes coding for diverse virulence factors such as Panton-Valentine leukocidin, staphylokinase, enterotoxins, chemotaxis-inhibitory proteins, or exfoliative toxins. Phages also mediate the transfer of pathogenicity islands in a highly coordinated manner and are the primary vehicle for the horizontal transfer of chromosomal and extra-chromosomal genes. Here, we summarise recent advances regarding phage classification, genome organisation and function of S. aureus phages with a particular emphasis on their role in the evolution of the bacterial host. (C) 2013 Elsevier B.V. All rights reserved.
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