期刊
INFECTION GENETICS AND EVOLUTION
卷 12, 期 7, 页码 1341-1343出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2012.04.024
关键词
Genotyping; Genetic diversity; Lineages; Dtu; Phylogeography; Trypanosoina Cruzi Strains
资金
- FOMIX CONACyT-Gobierno del Estado de Veracruz [VER-2008-C02-108783]
Chagas disease (or American trypanosomiasis) is a parasitic disease of major public health importance, caused by Trypanosoma cruzi, which presents extensive genetic diversity. The parasite has been classified into six lineages or discrete typing units (Tcl to TcVI) and we performed here the molecular characterization of the strains present in Triatoma dimidiata, the main vector in central Veracruz, Mexico. Unexpectedly, Tcl only represented 9/33 strains identified (27%), and we reported for the first time the presence of TcII, TcIII, TcIV and TcV strains in Mexico, at a relatively high frequency (13-27% each). Our observations indicate a much greater diversity of T. cruzi DTUs than previously estimated in at least part of Mexico. These results have important implications for the understanding of the phylogeography of T. cruzi DTUs and the epidemiology of Chagas disease in North America. (c) 2012 Elsevier B.V. All rights reserved.
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