期刊
INFECTION GENETICS AND EVOLUTION
卷 11, 期 5, 页码 878-885出版社
ELSEVIER
DOI: 10.1016/j.meegid.2011.02.007
关键词
Dengue virus type 4; Evolution; Phylogeography; Phylodynamics
资金
- FAPESP [2008/10713-6]
- CAPES
- CNPq - PQ
Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype. (C) 2011 Elsevier B.V. All rights reserved.
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