期刊
INFECTION GENETICS AND EVOLUTION
卷 10, 期 8, 页码 1282-1285出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2010.07.021
关键词
Escherichia coli O157:H7; SNPs; Evolution
资金
- National Institutes of Health [AI47499, R56AI063282, DK52081, 5P30 DK052574, 5T32AI007172]
Escherichia coli O157:H7 is a human pathogen that has emerged from its less pathogenic progenitor, E. coli O55:H7, to form the EHEC 1 clade. In its emergence, E. coli O157:H7 formed three distinct clusters, each of which exists today. Sequencing and SNP analysis of Cluster 1 of this clade demonstrated constrained radiation from the cluster founder. Here we investigated the diversity of Cluster 2 strains by sequencing signature SNPs in six strains collected throughout Washington State. Our results suggest that successful Cluster 2 strains have radiated on only two branches from their founder; one of these two branches leads to Cluster 3. Constrained radiation appears to be a common theme among this pathogenic clade. (C) 2010 Published by Elsevier B.V.
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