期刊
INFECTION GENETICS AND EVOLUTION
卷 8, 期 5, 页码 657-663出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2008.06.006
关键词
Drug resistance; Mutation; Spoligotyping; VNTR
资金
- NATO's Public Diplomacy Division [SFP-982319]
- FEMS
- European Commission [MIF1-CT-2007-039389]
- NATO's Public Diplomacy Division [SFP-982319]
- FEMS
- European Commission [MIF1-CT-2007-039389]
We report results of the first study on the molecular basis of drug resistance in Mycobacterium tuberculosis strains currently circulating in Bulgaria. The study panel consisted of 133 (including 37 drug-resistant) isolates recovered from newly diagnosed, adult pulmonary TB patients from different regions of Bulgaria in 2005-2006. Three types of the rpoB mutations were found in 20 of 27 RIF-resistant isolates; rpoB S531L was the most frequent. Eleven (48%) of 23 INH-resistant isolates had katG S315T mutation. inhA - 15C > T mutation was detected in one INH-resistant isolate (that also had katG315 mutation) and three INH-susceptible isolates. A mutation in embB306 was found in 7 of 11 EMB-resistant isolates. Comparison with spoligotyping and 24-VNTR locus typing data suggested that emergence and spread of drug-resistant and MDR-TB in Bulgaria are not associated with any specific spoligotype or MIRU-VNTR genotype. (C) 2008 Elsevier B.V. All rights reserved.
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