Carbapenem De-escalation Therapy in a Resource-Limited Setting

Pulmonary infection (P = .01) and an infectious diseases consultation (P = .04) were associated with carbapenem de-escalation; pulmonary infection and septic shock were associated with unsuccessful de-escalation. Successful de-escalaltion was associated with lower mortality (0% vs 23%; P < .001) and shorter duration of carbapenem use (4 vs 10 days; P <= .001).