期刊
INFECTION AND IMMUNITY
卷 82, 期 6, 页码 2565-2573出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.01594-14
关键词
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资金
- Departamento Administrativo de Ciencia, Tecnolog a e Inovacion Colciencias [4442013-111556933361]
- Universidad de Antioquia
- Banco de la Republica [201218-3069]
- Canadian Institutes of Health Research [115440, MOP 125971, MOP 115160, 13721]
- Global Alliance to Prevent Prematurity and Stillbirth and Grand Challenges in Global Health: Preventing Preterm Birth Initiative [12003]
- Canadian Research Chair
- CIHR Doctoral Research Award
- DVS-Maturation-IRD [DVS-2011]
- Agence Inter-etablissements de Recherche pour le Developpement
In pregnancy, parity-dependent immunity is observed in response to placental infection with Plasmodium falciparum. Antibodies recognize the surface antigen, VAR2CSA, expressed on infected red blood cells and inhibit cytoadherence to the placental tissue. In most settings of malaria endemicity, antibodies against VAR2CSA are predominantly observed in multigravid women and infrequently in men, children, and nulligravid women. However, in Colombia, we detected antibodies against multiple constructs of VAR2CSA among men and children with acute P. falciparum and Plasmodium vivax infection. The majority of men and children (> 60%) had high levels of IgGs against three recombinant domains of VAR2CSA: DBL5 epsilon, DBL3X, and ID1-ID2. Surprisingly, these antibodies were observed only in pregnant women, men, and children exposed either to P. falciparum or to P. vivax. Moreover, the anti-VAR2CSA antibodies are of high avidity and efficiently inhibit adherence of infected red blood cells to chondroitin sulfate A in vitro, suggesting that they are specific and functional. These unexpected results suggest that there may be genotypic or phenotypic differences in the parasites of this region or in the host response to either P. falciparum or P. vivax infection outside pregnancy. These findings may hold significant clinical relevance to the pathophysiology and outcome of malaria infections in this region.
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