期刊
INFECTION AND IMMUNITY
卷 80, 期 8, 页码 2704-2711出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00147-12
关键词
-
资金
- Wellcome Trust [098051, WT086418MA]
- MRC NIRG [G0901743]
- MRC [G0800170]
- Medical Research Council [G0800170, G0901743] Funding Source: researchfish
- MRC [G0800170, G0901743] Funding Source: UKRI
Clostridium difficile is a major cause of chronic antibiotic-associated diarrhea and a significant health care-associated pathogen that forms highly resistant and infectious spores. Spo0A is a highly conserved transcriptional regulator that plays a key role in initiating sporulation in Bacillus and Clostridium species. Here, we use a murine model to study the role of the C. difficile spo0A gene during infection and transmission. We demonstrate that C. difficile spo0A mutant derivatives can cause intestinal disease but are unable to persist within and effectively transmit between mice. Thus, the C. difficile Spo0A protein plays a key role in persistent infection, including recurrence and host-to-host transmission in mice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据