期刊
INFECTION AND IMMUNITY
卷 79, 期 10, 页码 3940-3946出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00148-11
关键词
-
资金
- National Institutes of Health [AR43520, AI45666, AI36333, AI054546]
Little is known regarding the function of gamma delta T cells, although they accumulate at sites of inflammation in infections and autoimmune disorders. We previously observed that gamma delta T cells in vitro are activated by Borrelia burgdorferi in a TLR2-dependent manner. We now observe that the activated gamma delta T cells can in turn stimulate dendritic cells in vitro to produce cytokines and chemokines that are important for the adaptive immune response. This suggested that in vivo gamma delta T cells may assist in activating the adaptive immune response. We examined this possibility in vivo and observed that gamma delta T cells are activated and expand in number during Borrelia infection, and this was reduced in the absence of TLR2. Furthermore, in the absence of gamma delta T cells, there was a significantly blunted response of adaptive immunity, as reflected in reduced expansion of T and B cells and reduced serum levels of anti-Borrelia antibodies, cytokines, and chemokines. This paralleled a greater Borrelia burden in gamma delta-deficient mice as well as more cardiac inflammation. These findings are consistent with a model of gamma delta T cells functioning to promote the adaptive immune response during infection.
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