期刊
INFECTION AND IMMUNITY
卷 78, 期 9, 页码 3753-3762出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00502-09
关键词
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资金
- Health Research Council of New Zealand
- Marjorie Barclay Trust
- Marsden Fund
- AMI Insurance Ltd.
- NIH NIAID [Z01 AI000493.22]
The rodent hookworm Nippostrongylus brasiliensis typically infects its host by penetrating the skin and rapidly migrating to the lungs and gut. Following primary infection, immunocompetent mice become highly protected from reinfection with N. brasiliensis, with the numbers of worms gaining access to the lungs and gut being reduced by up to 90%. We used green fluorescent protein/interleukin-4 (IL-4) reporter mice and truncated infection studies to identify both the tissue site and mechanism(s) by which the host protects itself from reinfection with N. brasiliensis. Strikingly, we demonstrated that the lung is an important site for priming immune protection. Furthermore, a lung-initiated, CD4 T-cell-dependent, and IL-4- and STAT6-dependent response was sufficient to confer protection against reinfection. In conclusion, vaccination strategies which seek to break the cycle of reinfection and egg production by helminths such as hookworms can include strategies which directly stimulate Th2 responses in the lung.
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