期刊
INFECTION AND IMMUNITY
卷 77, 期 5, 页码 2043-2050出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.01388-08
关键词
-
资金
- French Ministry of Health and Education
- French medical research council (INSERM)
- Pfizer
Staphylococcus aureus can produce a wide variety of exotoxins, including toxic shock syndrome toxin 1 (TSST-1), staphylococcal enterotoxins, and staphylococcal enterotoxin-like toxins. These toxins share super-antigenic activity. To investigate the beta chain (V beta) specificities of each of these toxins, TSST-1 and all known S. aureus enterotoxins and enterotoxin-like toxins were produced as recombinant proteins and tested for their ability to induce the selective in vitro expansion of human T cells bearing particular V beta T-cell receptors (TCR). Although redundancies were observed between the toxins and the V beta populations, each toxin induced the expansion of distinct V beta subsets, including enterotoxin H and enterotoxin-like toxin J. Surprisingly, the V beta signatures were not associated with a specific phylogenic group of toxins. Interestingly, each human V beta analyzed in this study was stimulated by at least one staphylococcal superantigen, suggesting that the bacterium derives a selective advantage from targeting the entire human TCR V beta panel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据