期刊
INDUSTRIAL HEALTH
卷 48, 期 6, 页码 783-795出版社
NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
DOI: 10.2486/indhealth.MS1129
关键词
Multiwall carbon nanotube; Neutrophils; Alveolar macrophages; Granuloma; Fibrosis; Alveolar wall thickening; Type II cell hyperplasia; Multinucleated cell
资金
- Ministry of Health, Labour and Welfare of Japan
In order to assess pulmonary toxicity of multiwall carbon nanotubes (MWCNT), male F344 rats were intratracheally instilled with MWCNT suspension at a dose of 40 or 160 mu g/head or alpha-quartz particles as a positive control at a dose of 160 mu g/head and sacrificed for lung his topathology and bronchoalveolar lavage (BAL) fluid analyses on Day 1, 7, 28 or 91 after instil lawn Well-dispersed MWCNT brought about dose or time-dependent changes in lung weight, total proteins, albumin, lactate dehydrogenase and alkaline phosphatase in the BAL fluid, and pulmonary lesions including inflammation, Type II cell hyperplasia, microgranulomas and fibrosis Phagocytosed and free forms of MWCNT were found in both bronchiolar and alveolar spaces MWCNT deposition in the bronchus-associated lymphoid tissue gradually Increased after instillation Persistent infiltration of macrophages, transient infiltration of Inflammatory cells primarily composed of neutrophils, microgranulomas associated with macrophages engulfing MWCNT, Type II cell hyperplasia and fibrosis with alveolar wall thickening as well as number of multinucleated alveolar macrophages increased dose-dependently The MWCNT-induced lesions were more potent on Day 91 than the a-quartz-Induced ones at an equal mass dose The present results for intratracheally instilled MWCNT were extrapolated to potential inhalation exposure of humans to MWCNT at workplaces based on several assumptions
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