期刊
INDUSTRIAL HEALTH
卷 46, 期 5, 页码 484-489出版社
NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
DOI: 10.2486/indhealth.46.484
关键词
asbestos; asbestosis; pleural hyalinosis; 8-isoprostane; breath condensate; rheumatoid factor; alpha 1-microglobulin; alpha 1-antitrypsin; cotinine
资金
- [IGA NR 9338-3/2007]
Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbestos workers with mean age 68.8 +/- 1.7 yr and mean duration of asbestos exposure 24.1 +/- 2.0 yr. The control group had 46 subjects with mean age 65.2 +/- 3.3 yr. The mean level of 8-isoprostane, analyzed by liquid chromatography -electrospray ionization- mass spectrometry, was higher in asbestos-exposed subjects (69.5 +/- 6.6 pg/ml, p=0.0001) compared with the control group, where the concentration was 47.0 +/- 7.8 pg/ml. The results presented support the hypothesis that oxidative stress due to asbestos is the main cause of increased 8-isoprostane in EBC. Measurement of 8-isoprostane in EBC is a promising non-invasive means for assessing the activity of asbestos-induced diseases.
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