期刊
INDUSTRIAL CROPS AND PRODUCTS
卷 61, 期 -, 页码 422-429出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.indcrop.2014.07.026
关键词
Sapindus mukorossi Gaertn; Bioactive; Graded; Antimicrobial activity; Antineoplastic activity
资金
- key project of transformation and industrialization of scientific and technological achievement in Fujian Province [2012N3008]
- National Natural Science Foundation of People' Republic of China [21203076]
- State Key Laboratory of Supramolecular Structure and Materials [sklssm 201328]
- Jiangsu province science and technology support program for social development [BE2012631]
- Fundamental Research Funds for the Central Universities [JUSRP51309A]
- National Key Technology R&D Program in the 12th Five year Plan of China [2012BAD36B02, 2014BAD04B03]
- Priority Academic Program Development of Jiangsu Higher Education Institution (PAPD)
The pericarp of Sapindus mukorossi Gaertn was used as raw material to extract crude saponin for the preparation of graded samples (fraction a-fraction g). The peak area revealed high total saponin content in fraction g. Based on molecular weights and peak appearance times, we speculated that the main components of total saponins of S. mukorossi Gaertn. include Sapindoside B, Sapindoside A, Mukurozisaponin E1, Sapindoside L, Mukurozi-saponin G and Sapindoside M. Analysis of the antibacterial and antineoplastic activities of different grade products showed that S. mukorossi Gaertn. and sesquiterpene glycosides display strong antimicrobial activity against dermatophytes, but not bacteria. The ethyl acetate extract displayed strong activity against both bacteria and dermatophytes, presenting blue fluorescence under UV light. In addition, the saponin mixture from S. mukorossi Gaertn. exerted a significant inhibitory effect on growth of the human breast cancer cell line, MCF-7, in vitro. (C) 2014 Elsevier B.V. All rights reserved.
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