Structure-Property Relationships for a Series of Poly(ester amide)s, Containing Amino Acids

Poly(ester amide)s (PEAs) composed of variable diols, dicarboxylic acids, and a-amino acids were synthesized and characterized to elucidate structure property relationships. The PEAs were synthesized using both solution and interfacial approaches to obtain varying molecular weights (MWs) and polydispersities. Studies using differential scanning calorimetry and powder X-ray diffraction revealed a range of amorphous and semicrystalline behavior that was dependent on structure. The viscosities of the PEAs as a function of temperature were studied by rheology, and phase transitions were confirmed for some polymers. Mechanical properties were also investigated, and it was found that the PEAS could be tuned to exhibit elastomeric or brittle behavior by varying both the length of the diol and the amino acid moiety. This information provides new insights into the effects of PEA structure, MW, and MW distribution on PEA properties and will aid in the design and selection of PEAS with optimal properties for targeted applications.