期刊
MATURITAS
卷 80, 期 1, 页码 52-57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2014.10.010
关键词
SERM; Menopause; Breast cancer; Osteoporosis; Endometrial cancer
SERMs represent a diverse group of molecules with varying levels of estrogenic agonist and antagonist activity in target tissues. SERMs have a long regulatory approval history and have been studied for a variety of therapeutic indications. The clinical effects of SERMs have been evaluated in a large number of phase 3 clinical trials. Many of the available SERMs have proved to be effective as chemo-preventive agents and treatments for breast cancer and a number are useful for the prevention and treatment of osteoporosis. The endometrial effect of SERMs has been a key differentiator in clinical practice and a major hurdle for regulatory approval. The effect of SERMs in the vagina also represents a major distinction among different SERMs. This review summarized key clinical finding of SERMs in different target tissues. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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