期刊
MATRIX BIOLOGY
卷 44-46, 期 -, 页码 46-53出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2015.04.001
关键词
Procollagen N-proteinases; ADAMTS; Fibrillar collagens
资金
- European postdoctoral fellowship (BeIPD-CO-FUND-IPD)
- Televie [7.4602.14]
- FRS-FNRS [T.0183.13]
Collagen fibers are the main components of most of the extracellular matrices where they provide a structural support to cells, tissues and organs. Fibril-forming procollagens are synthetized as individual chains that associate to form homo- or hetero-trimers. They are characterized by the presence of a central triple helical domain flanked by amino and carboxy propeptides. Although there are some exceptions, these two propeptides have to be proteolytically removed to allow the almost spontaneous assembly of the trimers into collagen fibrils and fibers. While the carboxy-propeptide is mainly cleaved by proteinases from the tolloid family, the amino-propeptide is usually processed by procollagen N-proteinases: ADAMTS2, 3 and 14. This review summarizes the current knowledge concerning this subfamily of ADAMTS enzymes and discusses their potential involvement in physiopathological processes that are not directly linked to fibrillar procollagen processing. (C) 2015 Published by Elsevier B.V.
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