期刊
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
卷 48, 期 11, 页码 5276-5284出版社
AMER CHEMICAL SOC
DOI: 10.1021/ie801295y
关键词
-
资金
- National Natural Science Foundation of China
- Hi-tech Research and Development Program of China [2006AA02Z210]
- Scientific and Technologic Program of Zhejiang Province
A novel polyelectrolyte complex (PEC) formed by sodium cellulose sulfate (NaCS) and chitosan was prepared as a potential material for a colon-specific drug delivery system. The characteristics of NaCS-chitosan film were measured by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), in vitro degradation, and in vitro drug release experiments. SEM data indicated that the NaCS-chitosan film had relatively homogeneous and smooth morphology at the initial state and deformed after being immersed in simulated colonic fluid (SCF). FTIR data indicated that the NH3+ of the chitosan had reacted with the SO4- of the NaCS. In vitro degradation behavior revealed that NaCS-chitosan could be degraded by colon microflora and be hydrolyzed in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). It is found in the experiment of in vitro drug release that the capsules formed by the NaCS-chitosan complex could release about 80% of the drug loaded in the SCF during 4 h. All these results indicated that the NaCS-chitosan complex shows excellent behavior for colon specificity and could be a potential material for a colon-specific drug, delivery system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据