期刊
INDOOR AIR
卷 20, 期 2, 页码 159-167出版社
WILEY
DOI: 10.1111/j.1600-0668.2009.00635.x
关键词
Air pollution; Indoor; Infant; Cough; Lung symptoms; Wheezing
类别
资金
- Pharmacy Foundation
- Lundbeck Foundation
- Augustino Foundation
- Ronald McDonald House Charities
- Danish Medical Research Council
- Danish Pediatric Asthma Center
- cand.pharm. K. Gad Andersen og Hustrus Familiefond
- Aage Bangs Fond
- Danish Lung Association
- Kai Lange og Gunhild Kai Langes Fond
- Direktor Ib Henriksens Fond
- Gerda og Aage Hensch's Fond
- Rosalie Petersens Fond
- Hans og Nora Buchards Fond
- Dagmar Marshalls Fond
- Foundation of Queen Louise' Children Hospital
- Danish Hospital Foundation for Medical Research, Region of Copenhagen
- Danish Hospital Foundation for Medical Research, Faroe Island
- Danish Hospital Foundation for Medical Research, Greenland
- Gangsted Fond
- Hojmosegard-Legatet
- Fonden til Laegevidenskabens Fremme
- A.P. Moller og Hustru Chastine Mc-Kinney Mollers Fond til almene Formaal
- Danish Ministry of the Interior
- Health's Research Centre for Environmental Medicine
- AstraZenaca
- LEOpharma
- Pharmacia-Pfizer
- Yamanouchi Pharma
P>Long-term exposure to air pollution is suspected to cause recurrent wheeze in infants. The few previous studies have had ambiguous results. The objective of this study was to estimate the impact of measured long-term exposure to indoor air pollution on wheezing symptoms in infants. We monitored wheezing symptoms in diaries for a birth cohort of 411 infants. We measured long-term exposure to nitrogen oxides (NOx), NO2, formaldehyde, PM2.5 and black smoke in the infants' bedrooms and analyzed risk associations during the first 18 months of life by logistic regression with the dichotomous end-point 'any symptom-day' (yes/no) and by standard linear regression with the end-point 'number of symptom-days'. The results showed no systematic association between risk for wheezing symptoms and the levels of these air pollutants with various indoor and outdoor sources. In conclusion, we found no evidence of an association between long-term exposure to indoor air pollution and wheezing symptoms in infants, suggesting that indoor air pollution is not causally related to the underlying disease. Practical Implications Nitrogen oxides, formaldehyde and fine particles were measured in the air in infants' bedrooms. The results showed no evidence of an association between long-term exposure and wheezing symptoms in the COPSAC birth cohort.
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