期刊
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
卷 52, 期 4, 页码 S63-S70出版社
ASSOC PHARMACEUTICAL TEACHERS INDIA
DOI: 10.5530/ijper.52.4s.77
关键词
Pterostilbene; Stability-Indicating; RP-HPLC; Validation; ICH guidelines
资金
- University Grants Commission, New Delhi, India
Introduction: Pterostilbene, a stilbenoid possess diversified pharmacological activities. In the present study, a stability-indicating liquid chromatographic method was proposed for the determination of Pterostilbene in pharmaceutically available formulations. Materials and Methods: The chromatographic separation was achieved on Phenomenex C8 type column as stationary phase. UV detection was carried out at 219 nm. Pterostilbene was subjected to various stress conditions such as acidic, alkaline, oxidative, thermal and photolytic degradations. Results:The drug was found to be sensitive towards acidic and alkaline stress conditions. The proposed method was validated as per the ICH guidelines and successfully applied to the available marketed formulations. Conclusion: The proposed method is selective, specific, robust and can be applied for the assay of pharmaceutical dosage forms.
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