期刊
INDIAN JOURNAL OF ORTHOPAEDICS
卷 44, 期 4, 页码 363-368出版社
SPRINGER HEIDELBERG
DOI: 10.4103/0019-5413.69304
关键词
Ewing's sarcoma; EWS-FLI1 translocation; pathology; PNET
类别
Ewing's sarcoma/PNET are small round cell tumors showing a varying degree of neuroectodermal differentiation. They are one of the commonest tumors of childhood and occur in bone and within soft tissues. Traditionally, light microscopy with the aid of immunohistochemical stains was suitable for diagnosis. But now translocation analyses are being used not only for the diagnosis and classification of small round cell tumors, but to ascertain their prognostic significance, detect micrometastasis, and monitor minimal residual disease, with potential for targeted therapy. This article analyzes the pathology, biology, and molecular aspects of Ewing's sarcoma/PNET and discusses their clinical and therapeutic implications.
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