4.1 Article

Azithromycin Reduces the Production of α-hemolysin and Biofilm Formation in Staphylococcus aureus

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INDIAN JOURNAL OF MICROBIOLOGY
卷 54, 期 1, 页码 114-117

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SPRINGER
DOI: 10.1007/s12088-013-0438-4

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Staphylococcus aureus; Azithromycin; Biofilm; alpha-hemolysin

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Staphylococcus aureus causes a broad range of life-threatening diseases in humans. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases which are controlled by quorum sensing. In this study, we show that azithromycin was active against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranged from 32 to 64 mu g/mL. Azithromycin at subinhibitory concentration, markedly reduced the production of alpha-hemolysin at (1/16MIC, 1/8MIC) and biofilm formation at (1/16MIC, 1/8MIC), respectively. The results indicated that sub-inhibitory concentrations of azithromycin decreased the production of alpha-hemolysin and biofilm formation in MRSA in a dose-dependent manner. Therefore, azithromycin may be useful in the treatment of alpha-hemolysin producing and biofilm formation MRSA infections.

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