期刊
INDIAN JOURNAL OF CANCER
卷 49, 期 1, 页码 137-143出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0019-509X.98940
关键词
Ataxia Telangiectasia Mutation; immunoglobulin heavy chain variable region; somatic hyper mutation; Zeta associated protein
类别
Chronic lymphocytic leukemia (CLL) was largely considered to be a disease of slow progression, standard treatment with Chlorambucil and having almost similar prognosis. With the introduction of molecular methods for understanding the disease pathophysiology in CLL there has been a remarkable change in the approach towards the disease. The variation in B-cell receptor response and immunoglobulin heavy chain variable region (IGHV) mutation, genetic aberration and defect in apoptosis and proliferation has had an impact on therapy initiation and prognosis. Early diagnosis of molecular variant is therefore necessary in CLL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据