期刊
IMMUNOTHERAPY
卷 5, 期 10, 页码 1075-1087出版社
FUTURE MEDICINE LTD
DOI: 10.2217/imt.13.102
关键词
cancer; CCR2; CSF1R; macrophage; therapeutic
类别
资金
- Lustgarten Foundation
- V Foundation
- A Edward Mallinckrodt Jr Award
- Cancer Research Foundation
- Cancer Frontier Fund
Tumor-associated macrophages are one of the major constituents of tumor stroma in many solid tumors and there is compelling preclinical and clinical evidence that macrophages promote cancer initiation and malignant progression. Therefore, these cells represent potential targets for therapeutic benefit. In this review, we will summarize macrophage phenotypic heterogeneity, the current understanding of how tumors take advantage of macrophage plasticity to generate immunosuppression, and how manipulation of specific macrophage populations can be used for therapeutic purposes through translational approaches.
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