期刊
IMMUNOTHERAPY
卷 5, 期 4, 页码 407-414出版社
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.13.23
关键词
adoptive T-cell therapy; adoptive T-cell transfer; antiretroviral therapy; ART; CAR; chimeric antigen receptor; zinc finger nuclease
类别
资金
- Baylor-UT Houston Center for AIDS Research Core Support Grant from the National Institute of Allergy and Infectious Diseases [AI36211]
Antiretroviral therapy has improved the quality of life for HIV+ individuals but efficacy requires strict adherence and treatment is not curative. Recently, the use of T cells as therapeutic agents has been in the spotlight in the settings of post-transplant opportunistic infections and cancer. Whether T-cell therapy can be harnessed for treating HIV remains to be determined but there are a few studies that seek to answer that question. Infusion of ex vivo-expanded HIV-specific T cells showed limited efficacy but no adverse events. Genetically modified T cells expressing CD4 chimeric antigen receptors have recently been shown to have persistence that outperforms chimeric antigen receptors used for cancers. Although the results have not yet been published for many clinical studies using T cells for HIV, preclinical studies and the clinical data that are available highlight the potential for T-cell therapy to decrease or eliminate HIV patients' dependency on antiretroviral therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据