期刊
IMMUNOTHERAPY
卷 2, 期 3, 页码 305-327出版社
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.10.17
关键词
aberrant O-linked glycosylation; cancer; episialin; immunotherapy; MUC1; polymorphic epithelial mucin
类别
资金
- Cancer Research UK (61 Lincoln's Inn Fields, London WC2A 3PX, UK) [1089464]
- King's College London (The Strand, London WC2R 2LS, UK)
The overexpression and aberrant glycosylation of MUC1 is associated with a wide variety of cancers, making it an ideal target for immunotherapeutic strategies. This review highlights the main avenues of research in this field, focusing on adenocarcinomas, from the preclinical to clinical; the problems and possible solutions associated with each approach; and speculates on the direction of MUC1 immunotherapeutic research over the next 5-10 years.
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