期刊
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
卷 33, 期 3, 页码 525-532出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08923973.2010.547500
关键词
Vanillic acid; inflammation; tumor necrosis factor-alpha; interleukin-6; nuclear factor-kappa B; caspase-1
资金
- Ministry of Education, Science and Technology (MEST) [R13-2008-028-01000-0]
Vanillic acid is a benzoic acid derivative that is used as a flavoring agent. It is an oxidized form of vanillin. At present, the mechanisms by which vanillic acid exerts its anti-inflammatory effects are incompletely understood. In this study, we attempted to determine the effects of vanillic acid on lipopolysaccharide (LPS)-induced inflammatory responses in mouse peritoneal macrophages. Our findings indicate that vanillic acid inhibits LPS-induced production of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. During the inflammatory process, the levels of cyclooxygenase (COX)-2 and nitric oxide (NO) increased in mouse peritoneal macrophages, but vanillic acid suppressed both the enhanced levels of COX-2 and the production of prostaglandin E 2 and NO. Moreover, vanillic acid suppressed the activation of nuclear factor-kappa B (NF-kappa B) and caspase-1. These results provide novel insights into the pharmacological actions of vanillic acid and are indicative of the potential use of this molecule in the treatment of inflammatory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据