期刊
IMMUNOLOGY LETTERS
卷 158, 期 1-2, 页码 14-24出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2013.11.013
关键词
Toll-like receptors; Aquatic animals; Fish; Innate immunity
类别
资金
- Ministry of Human Resource Development, Government of India
- National Fund for Basic, Strategic and Frontier Application Research in Agriculture (NFBSFARA), Indian Council of Agricultural Research (ICAR), Government of India [NFBSFARA/BS-4003]
The innate system's recognition of non-self and danger signals is mediated by a limited number of germline encoded pattern recognition receptors (PRRs) that recognize pathogen associated molecular patterns (PAMPs). Toll-like receptors (TLRs) are single, non-catalytic, membrane-spanning PRRs present in invertebrates and vertebrates. They act by specifically recognizing PAMPs of a variety of microbes and activate signaling cascades to induce innate immunity. A large number of TLRs have been identified in various aquatic animals of phyla Cnidaria, Annelida, Mollusca, Arthropoda, Echinodermata and Chordata. TLRs of aquatic and warm-blooded higher animals exhibit some distinctive features due to their diverse evolutionary lineages. However, majority of them share conserve signaling pathways in pathogen recognition and innate immunity. Functional analysis of novel TLRs in aquatic animals is very important in understanding the comparative immunology between warm-blooded and aquatic animals. In additions to innate immunity, recent reports have highlighted the additional roles of TLRs in adaptive immunity. Therefore, vaccines against many critical diseases of aquatic animals may be made more effective by supplementing TLR activators which will stimulate dendritic cells. This article describes updated information of TLRs in aquatic animals and their structural and functional relationship with warm-blooded animals. (C) 2013 Elsevier B.V. All rights reserved.
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