期刊
IMMUNOLOGY LETTERS
卷 162, 期 1, 页码 248-255出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2014.09.013
关键词
Mesenchymal stem cells; Programmed cell death-1 receptor(PD-1); PD-1/B7-H1 pathway; Apoptosis; Immunosuppression
类别
资金
- Science and Technology Projects and Social Development of Guangdong Province (China) [20108031600082]
- State Key Laboratory of Respiratory Disease (China) [2007DA80154F1107]
- Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-Sen University [KLB09001]
- Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology [20131163]
Mesenchymal stem cells (MSCs) exert a suppressive role toward T cells which has been widely studied in recent decades. However, the underlying mechanisms utilized by MSCs are still not fully elucidated. Herein, we performed traditional suppressive assays using co-cultured MSCs and conventional CD4(+)CD25(-) T cells (Tconv) with and without transwell systems. We showed that the expression of programmed cell death-1 receptor (PD-1) on activated Tconv was significantly elevated after they were exposed to MSCs. And we demonstrated that PD-1/B7-H1 pathway was involved in the suppression of MSCs on activated Tconv. Further analysis revealed that the up-regulation of PD-1 was related to an increasing apoptosis of activated Tconv. Finally, we demonstrated that the PD-1/B7-H1 pathway was not related to the elevated immunosuppressive cytokines including IL-10 and TGF-beta(1) which in turn played dispensable roles in the up-regulation of PD-1 on activated Tconv in MSC-Tconv co-culture systems. (C) 2014 Elsevier B.V. All rights reserved.
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