期刊
IMMUNOLOGY LETTERS
卷 154, 期 1-2, 页码 42-48出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2013.08.006
关键词
Idiopathic thrombocytopenic purpura; T cell subset; Dexamethasone; Transcription factor
类别
Idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disorder. Both impaired platelet production and T cell-mediated effects play a role in ITP thrombocytopenia. A Th1 polarization of the immune response, up-regulation of Th17 cells and decreased number of Treg cells have been demonstrated in ITP patients. High-dose dexamethasone was administered as first-line therapy in adult patients with ITP. However, the mechanism of effects of dexamethasone on ITP is still unclear. In this study, we tested the effectiveness of high-dose dexamethasone as initial treatment in adults with immune thrombocytopenic purpura. PBMCs were isolated from Donors, ITP and Treatment groups. T cell subsets were analyzed by FCM and transcriptional factors were checked by Real-time PCR. We found that dexamethasone returned the ratio of Th1/Th2 and the number of Th17 and Treg cells to the normal levels. Furthermore, we identified that dexamethasone corrected the T cell subset levels through inhibiting GATA3 and FOXp3 expression and promoting ROR gamma t expression. Taken together, we reported a previously unrecognized mechanism on dexamethasone in the ITP treatment. (C) 2013 Elsevier B.V. All rights reserved.
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