期刊
IMMUNOLOGY LETTERS
卷 145, 期 1-2, 页码 10-14出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2012.04.005
关键词
Synergy; Migration; Leukocyte; Chemokine receptors; Heterodimers; Signalling
类别
资金
- European Union [LSHB-CT-2005-518167]
- InterUniversity Attraction Poles Program - Belgian Science Policy
- Fund for Scientific Research of Flanders (FWO-Vlaanderen, Belgium)
- Concerted Research Actions (GOA) of the Regional Government of Flanders
- DEC-VAC [LSHP-CT-2005-018685]
- Swiss National Science Foundation [3100A0-118048/1]
- San Salvatore Foundation
- Helmut Horten Foundation
The arrest and directed migration of leukocytes during homeostasis, tumour development and inflammation is orchestrated by a multitude of chemokines, which govern leukocyte migratory activities. Immune cells are particularly adept at adjusting rapidly to changes within the environment by migration in response to chemokines. The confrontation of leukocytes with different combination of chemokines that are concomitantly produced under physiological or pathological conditions in vivo is complex. There are different ways to enhance or reduce leukocyte migration mediated by chemokines such as posttranslational modifications. Here, we described a positive regulatory mechanism in leukocyte trafficking, by the synergism between chemokines to rapidly augment the local leukocyte influx, thereby enhancing the outcome of an inflammatory response in vivo. The cellular mechanisms involved in chemokine synergy are still debated, but probably include chemokine and/or receptor heterodimerization and subsequent cooperation in signal transduction. (C) 2012 Elsevier B.V. All rights reserved.
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