期刊
IMMUNOLOGY LETTERS
卷 141, 期 1, 页码 28-35出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2011.08.003
关键词
T cells; Dendritic cells; Phosphatidylserine; Asthma; Hepatitis A virus; Filovirus
类别
T cell, immunoglobulin domain and mucin domain-1 (TIM-1) is the nominant member of a small family of related proteins that regulate immune cell activities. TIM-1 was initially characterized in a mouse congenic analysis of Th2 T cell responses and related pathology. Data accumulated to date suggest that TIM-1 regulates effector T cell function, and may play distinct roles in the activities of B cells, invariant NKT cells and epithelial cells. In addition, a variety of ligands for TIM-1 have been proposed. In this review I discuss recent data that have accumulated on the function of TIM-1, propose a model to explain how TIM-1 regulates effector T cell activity through recognition of distinct ligands, and review others functions of this increasingly fascinating protein. Of considerable interest are the novel findings that TIM-1 mediates virus entry and virulence. (C) 2011 Elsevier B.V. All rights reserved.
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