期刊
IMMUNOLOGY LETTERS
卷 137, 期 1-2, 页码 9-14出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2011.02.019
关键词
T cells; Toll-like Receptors; TLR; TLR agonists; TLR ligands; TLR expression; Vaccination
类别
Traditionally, expression of toll-like receptors (TLRs) has been associated with innate immune cells in particular professional antigen presenting cells and natural killer cells. This led to the concept that the adjuvant effects of ligation of TLR in a host occur mainly in innate immune cells. However, this concept has been challenged by recent studies including ours demonstrating that T cells express appreciated levels of different TLRs, which can serve as costimulatory co-receptors during polyclonal and antigen-specific stimulation of T cells. Because T cells express low levels of TLRs as compared to innate immune cells, increasing the expression levels of TLRs in T cells can significantly maximize their responses to the costimulatory effects of TLR ligation. This review article focuses on the potential role of TLR expression in T cells in their responses to vaccination regimen containing TLR agonists and how it can be modulated to optimize anti-tumor immunity. (C) 2011 Elsevier B.V. All rights reserved.
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