期刊
IMMUNOLOGY LETTERS
卷 128, 期 1, 页码 46-50出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2009.11.003
关键词
T cells; Suppression; Dendritic cells; VSIG4
类别
资金
- Nomarch Foundation for Excellent Talents of Science and Technology in Guizhou Province [(2005)230, (2009)31]
- Foundation of Guizhou Provincial Science and Technology Department [(2009)22211]
- National Natural Science Foundation of China [30772048]
- Natural Science Foundation of Chongqing [CSTC 2006BB5066]
- Clinical Innovative Foundation of Southwest Hospital [SWH2006A003]
VSIG4 has been recently described as a B7 family-related protein. The immunotherapeutic potential of dendritic cells (DCs) transfected with VSIG4 recombinant adenovirus has not been characterized. In the present study, DCs were transfected with human VSIG4 (hVSIG4) recombinant adenovirus, a novel costimulatory molecule known to be a potent inhibitor of T cell activation. Transfected DCs were cocultured with allogeneic T cells and proliferation, cytokine production and T cell activation marker expression were assessed. The results showed that T cell proliferation potential, cytokine production and activation marker expression were suppressed after coculture with hVSIG4 recombinant adenovirus-transfected DCs. These findings suggest that DCs transfected with hVSIG4 recombinant adenovirus are capable of inducing allogeneic T cell suppression, which represents an ideal strategy for manipulating the immune response to transplanation or autoimmune diseases. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据