期刊
IMMUNOLOGY LETTERS
卷 132, 期 1-2, 页码 69-78出版社
ELSEVIER
DOI: 10.1016/j.imlet.2010.06.002
关键词
Dendritic cell subsets; DCIR; ClecSF6; Monoclonal antibody generation; Antibody targeting
类别
资金
- German Research Foundation [SFB643/II-TP-A7, DU-548/1-1, DU-548/2-1, SFB643/II-TP-A8, FOR832]
- Bavarian State of Ministry of Sciences, Research and the Arts (BayGene)
- DAAD
- Celldex
Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral immune responses in vivo. Therefore, we investigated whether this novel strategy might also be useful for the generation of new monoclonal antibodies against molecules of choice. We show, that by targeting the extracellular domain of the human C-type lectin receptor ClecSF6/DCIR/LLIR (hDCIR) to DEC205 on DCs in vivo, we were able to generate highly specific monoclonal antibodies against hDCIR. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据