期刊
IMMUNOLOGY LETTERS
卷 122, 期 2, 页码 159-169出版社
ELSEVIER
DOI: 10.1016/j.imlet.2008.12.009
关键词
GVT; Thymus; Oxidative stress
类别
资金
- NIH [NS43984, MH71583, MH077470]
- Career Re-entry supplement [MH71583]
- NIEHS Center [ES07784, CA16672]
- Michale E. Keeling Center for Comparative Medicine and Research
- University of Texas M.D
- Anderson Cancer Center, Bastrop, TX
- Longevity Foundation of Austin
A mutant of MoMuLV, called ts1, causes an AIDS-like syndrome in susceptible strains of mice. In mice infected at birth, thymic atrophy, CD4+ T cell loss, body wasting, and death occur by similar to 30-40 days postinfection (dpi). We have shown previously that the death of ts1-infected cells is not caused by viral replication per se, but by oxidative stress and apoptosis following their accumulation the ts1 viral envelope precursor protein, gPr80(env). In infected mice treated with the antioxidant monosodium alpha-luminol (GVT (R)), T cell loss and thymic atrophy are delayed for many weeks, and body wasting and death do not occur until long after infected, untreated control mice have died. We show here that GVT treatment of ts1-infected mice maintains the thymic epithelial cell (TEC) cytoarchitecture and cytokeratin gradients required for thymocyte differentiation. It also suppresses thymocyte reactive oxygen species (ROS) levels, upregulates and stabilizes levels of the antioxidant-regulating transcription factor Nrf2, and prevents accumulation of gPr80(env) in thymocytes. We conclude that GVT treatment can make ts1 a non-cytopathic virus for thymocytes, although it cannot prevent thymocyte infection. Since oxidative stress also contributes to the loss of T cells in HIV-AIDS, the antioxidant effects of GVT may make it a useful therapeutic adjunct to HAART treatment. (C) 2009 Elsevier B.V. All rights reserved.
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