期刊
IMMUNOLOGY LETTERS
卷 115, 期 1, 页码 43-49出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2007.09.010
关键词
stress; adrenergic stimuli; hyperglycemia; hypothermia; innate immunity
类别
Mice were exposed to restraint stress for 3 h. During this period, low body temperature (hypothermia, 39 degrees C -> less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150 mg/dl -> up to 220 mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines increased at that time. Administration of adrenaline (alpha-stimulus), but neither noradrenaline (alpha but less than adrenaline) nor isoproterenol (beta), induced a similar stress-induced pattern of body temperature and blood glucose variations. This a-adrenergic effect was confirmed using alpha- and beta-blockers in adrenaline-induced hypothermia and hyperglycemia. By applying this alpha-stimulus, the effect on immunoparameters was then investigated. Stress-resistant lymphocyte populations were found to be NK cells, extrathymic T cells and NKT cells, especially in the liver. Functional assays showed that both NK-cell cytotoxicity and NKT-cell cytotoxicity were augmented by alpha-stimulus. These results suggest that alpha-stimulus is one of the important factors in the stress-induced phenomenon and that it eventually produces hypothermia, hyperglycemia and innate-immunity activation seen during stress. (C) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据