期刊
IMMUNOLOGY LETTERS
卷 116, 期 2, 页码 104-110出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2007.12.008
关键词
Akt; PI3K; thymocyte; TCR; Bcl-xL; metabolism
类别
资金
- NCI NIH HHS [P01 CA93615, P01 CA093615, P01 CA093615-06] Funding Source: Medline
- NIAID NIH HHS [R01 AI058019-05, R01 AI058019] Funding Source: Medline
- NIGMS NIH HHS [R01 GM053256, R01 GM053256-12] Funding Source: Medline
- PHS HHS [F31 A1056671] Funding Source: Medline
Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stage to the CD4(+)CD8(+) (double positive) stage. The PI3K/Akt signaling pathway is required to translate these extracellular signaling events into multiple functional outcomes including cellular survival, proliferation, differentiation, and allelic exclusion at the P-selection checkpoint. However, a complete understanding of the contributions made by the PI3K/Akt pathway in thymocyte development has not been straightforward. This review highlights studies that support the model that the PI3K/Akt pathway is essential for thymocyte survival. We provide new evidence that Akt-mediated survival is not solely due to the increased expression of Bcl-xL but also is a consequence of the role played by Akt to support metabolism in proliferating thymocytes. (C) 2007 Elsevier B.V. All rights reserved.
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