期刊
IMMUNOLOGY LETTERS
卷 117, 期 1, 页码 57-62出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2007.11.018
关键词
Mycobacterium tuberculosis; cytokine; human
类别
资金
- NIAID NIH HHS [1 AI-75320, R01 AI043348-07] Funding Source: Medline
IL-24 is a newly described member of the IL-10 family. We previously demonstrated that PBMC from TB patients exhibited low levels of IL-24 and IFN-gamma compared to subjects with latent tuberculosis infection (LTBI). In order to investigate the role of IL-24 in IFN-gamma expression in TB patients, we stimulated PBMC from individuals with LTBI or TB patients with the Mtb-specific antigen, early secretory antigenic target-6 (ESAT-6) and measured cytokine expression using quantitative real-time PCR (qPCR). Exogenous IL-24 increased IFN-gamma expression in PBMC obtained from TB patients while neutralization of IL-24 reduced IFN--y expression in PBMC from subjects with LTBI. Exogenous IL-24 enhanced IFN--y expression by increasing expression of IL-12 family cytokines, including IL-12 alpha, IL-12 beta, IL-23 alpha and IL-27, and by reducing FOXP3 expression in PBMC from TB patients. This is the first demonstration that IL-24 may play an important role in IFN--y expression following infection with Mtb. (C) 2007 Elsevier B.V. All rights reserved.
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