期刊
IMMUNOLOGY AND CELL BIOLOGY
卷 93, 期 2, 页码 198-212出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/icb.2014.94
关键词
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资金
- NHMRC [454569, 1013367]
- US Department of Defense [W81XWH-11-1-0585]
- INSERM
- National Health and Medical Research Council of Australia (NHMRC) Australia Fellowship [1013367]
- Cancer Research Institute PhD scholarship
- ARC Future Fellowship
- CNRS
- National Health and Medical Research Council of Australia (NHMRC) [1013367]
- NHMRC Senior Principal Research Fellowship [1020770]
- Leukaemia Foundation of Australia postgraduate scholarship
- Canadian Institutes of Health Research
- Crohn and Colitis Foundation of Canada
- Tier 2 Canada Research Chair
- Vanier Canada Graduate Scholarship
- Agence Nationale de la Recherche [ANR-10-LABX-46]
- Fondation de France
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune responses including infection, allergy and auto-immunity. gamma delta T cells are recognized as IL-17 producers, but based on the level of CD3 expression, we now define the remarkable ability of a CD3(bright) gamma delta T-cell subset with an effector memory phenotype to rapidly produce IL-17A, but not interferon-gamma. CD3(bright) gamma delta T cells uniformly express the canonical germline encoded V gamma 6/V delta 1(+) T-cell receptor. They are widely distributed with a preferential representation in the lungs and skin are negatively impacted in the absence of retinoic acid receptor-related orphan receptor gammat expression or endogenous flora. This population responded rapidly to various stimuli in a mechanism involving IL-23 and NOD-like receptor family, pyrin domain containing 3 (NLRP3)-inflammasome- dependent IL-1 beta. Finally, we demonstrated that IL-17-producing CD3(bright) gamma delta T cells responded promptly and strongly to pneumococcal infection and during skin inflammation. Here, we propose a new way to specifically analyze IL-17-producing V gamma 6/V delta 1(+) T cells based on the level of CD3 signals. Using this gating strategy, our data reinforce the crucial role of this gamma delta T-cell subset in respiratory and skin disorders.
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